Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 985-990, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-356030
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the impact on absorption of berberine and palmatine in different compatibilities of Wuji pill by the perfused rat intestine-liver preparation.</p><p><b>METHOD</b>Use L9 (3(4)) orthogonal design table, establish the perfused rat intestine-liver preparation, the twelve Wuji pill compatibilities duodenal administrated, collect the perfusate at different times points for LC-MS detection, calculate the absorbed score, Ka.</p><p><b>RESULT</b>Evodiae Fructus and the absorption score, Ka of berberine and palmatine are inverse correlated. The most superior portion which promote the absorption is Coptidis Rhizoma-Evodiae Fructus-Paeoniae Radix Alba 313.</p><p><b>CONCLUSION</b>Evodiae Fructus suppressed the absorption of berberine and palmatine. With the different portion the absorption also have big different.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Berberina
/
Alcaloides de Berberina
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Química
/
Evodia
/
Absorção Intestinal
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2012
Tipo de documento:
Artigo