Diabetes mellitus ulcers treatment with Bletilla striata polysaccharide / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1487-1491, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-356091
Biblioteca responsável:
WPRO
ABSTRACT
The aim of this study was to evaluate the efficacy of Bletilla striata polysaccharide on diabetes mellitus ulcers. Diabetes mellitus animal model was established by single ip injection of streptozotocin (STZ, 50 mg x kg(-1)) with the criteria of blood glucose > or = 16.7 mmol x L(-1) after 72 h. 4 weeks after STZ injection, each animal received two full thickness incisional wounds (1.8 cm in diameter). The wounds then were divided into B. striata polysaccharide group and PBS group. Wound closure rate, fibroblast (FB) infiltration, hydroxyproline (OHP) content and myeloperoxidase (MPO) levels were examined on day 3, 7, 14, 21 post wound. The treatment of B. striata polysaccharide significantly facilitated diabetes mellitus ulcers healing compared to PBS group. Histological analysis showed that B. striata polysaccharide markedly increased inflammatory cell infiltration in wound area. The herb also strongly evaluation of FB, OHP demonstrated a significantly increased in B. striata polysaccharide group. B. striata polysaccharide group promoted wound closure by means of enhanced inflammatory cell infiltration and re-epithelialization, and the promotion of FB and OHP levels.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polissacarídeos
/
Úlcera Cutânea
/
Cicatrização
/
Medicamentos de Ervas Chinesas
/
Extratos Vegetais
/
Peroxidase
/
Complicações do Diabetes
/
Diabetes Mellitus Experimental
/
Tratamento Farmacológico
/
Fibroblastos
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Artigo