Effects of inulae and ochrae decoction on the change of rabbits EGG and 5-HT resulted from chemotherapeutic drugs / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To explore the antagonism mechanism of inulae and ochrae decoction on toxicity damage of gastrointestinal tissue induced by DDP (cisplatin).</p><p><b>METHODS</b>Twenty-four healthy hybrid rabbits were divided into three groups in random the control group, DDP group, inulae and ochrae decoction + DDP group. The change of rabbits EGG, the concentration of 5-HT,5-HIAA of serum and the content of sinus ventriculi mucosa and the upper part of duodenum tissue were examined. Ultrastructure changes were observed by transmission electron microscope (TEM).</p><p><b>RESULTS</b>The EGG amplitude of DDP group was increased and the frequency was fast (P < 0.05) after i.v. DDP, meanwhile the concentration of 5-HT, 5-HIAA was increased (P < 0.05), and the content of sinus ventriculi mucosa and the upper part of duodenum tissue were higher than that of Inulae and Ochrae Decoction + DDP group (P < 0.05), and the change was seriously under the TEM observing; while inulae and ochrae decoction could prevent the change of EGG caused by DDP, showing the amplitude decreased, and the frequency was slow, and the concentration of 5-HT, 5-HIAA of serum and the content of tissue became lower than that of DDP group.</p><p><b>CONCLUSION</b>Inulae and ochrae decoction could antagonize the change of EGG caused by DDP, which maybe have relations with the over-releasing of gastrointestinal 5-HT.</p>