Research progress on chemokine receptor 5-targeted therapy for HIV-1 / 病毒学报
Chinese Journal of Virology
; (6): 79-83, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-356634
Biblioteca responsável:
WPRO
ABSTRACT
Along with the spread of human immunodeficiency virus 1 (HIV-1) infection in the world and the emergence of drug-resistant viral strains, it is urgent to seek the novel potent therapies. Chemokine receptor 5 (CCR5) is one of the main coreceptors involved in the entry of HIV-1 into target cells. Nowadays, a number of CCR5 antagonists have been developed and some of them have progressed to clinical trials or been approved. Research progress has also been made in the CCR5-targeted gene therapy. This review summarizes the recent research progress on the CCR5-targeted drug and gene therapy.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Infecções por HIV
/
HIV-1
/
Receptores CCR5
/
Tratamento Farmacológico
/
Terapia de Alvo Molecular
/
Antagonistas dos Receptores CCR5
/
Genética
/
Metabolismo
/
Métodos
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2014
Tipo de documento:
Artigo