Antivirus effects of extract from gardenia / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1176-1178, 2006.
Article
em Zh
| WPRIM
| ID: wpr-356712
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of the extract from gardenia on influenza viral pneumonia in mice and virus-induced cytopathic effect.</p><p><b>METHOD</b>The mice were infected by influenza virus in nasal, the lung inflammation, mortality rate and life elongation rate were observed respectively. The anti-viral activity of the extract from gardenia was accessed by cytopathic effect (CPE) in vitro and 0% toxicity concentration (TC0), 50% toxicity concentration (TC50), 50% inhibitor concentration (IC50), therapeutic index (TI) were determined by Reed-Muench method.</p><p><b>RESULT</b>The pneumonia induced by influenza virus in mice was inhibited significantly by the extract from gardenia, as the mortality rate decreased and the life elongation rate increased remarkably. Meanwhile the NO content in serum decreased significantly; The cytopathic effect induced by six kinds of viruses was inhibited remarkably.</p><p><b>CONCLUSION</b>The six kinds of viruses were inhibited significantly by the extract from gardenia which inhibitory effect on mice influenza viral pneumonia was related to the NO content decreased.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Antivirais
/
Orthomyxoviridae
/
Farmacologia
/
Plantas Medicinais
/
Pneumonia Viral
/
Virologia
/
Virulência
/
Sangue
/
Medicamentos de Ervas Chinesas
/
Distribuição Aleatória
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2006
Tipo de documento:
Article