An experimental study of energy controllable steep pulse in the treatment of rat with subcutaneous transplantive tumor / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 492-495, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-357667
Biblioteca responsável:
WPRO
ABSTRACT
This experimental study was designed to investigate the effects and the expressions of microvessel density (MVD), vascular endothelial growth factor (VEGF) on the transplanted tumor in the rat model with Walker-256 after energy controllable steep pulse(ECSP). The experiment revealed that the steep pulse electrical field has better effect on tumor, compared with the control. The positive cell staining intensity of VEGF in the control group was significantly higher than that in ECSP group (P < 0.05). The number of MVD in the tumor tissues of ECSP group was significantly lower than that of tumor control group (P < 0.05). These results showed that ECSP could inhibit the growth and angiogenesis of tumor and its pathway is to down-regulate the expression of VEGF possibly.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Carcinoma 256 de Walker
/
Terapia por Estimulação Elétrica
/
Ratos Wistar
/
Eletroporação
/
Fator A de Crescimento do Endotélio Vascular
/
Condutividade Elétrica
/
Campos Eletromagnéticos
/
Metabolismo
/
Métodos
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2007
Tipo de documento:
Artigo