Pulmonary pathology in fatal human influenza A (H1N1) infection / 中华病理学杂志
Chinese Journal of Pathology
; (12): 825-829, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-358226
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the pulmonary pathology in patients died of fatal human influenza A(H1N1) infection.</p><p><b>METHODS</b>Eight cases of fatal human influenza A (H1N1) infection, including 2 autopsy cases and 6 paramortem needle puncture biopsies, were enrolled into the study. Histologic examination, immunohistochemitry, flow cytometry and Western blotting were carried out.</p><p><b>RESULTS</b>The major pathologic changes included necrotizing bronchiolitis with surrounding inflammation, diffuse alveolar damage and pulmonary hemorrhage. Influenza viral antigen expression was detected in the lung tissue by Western blotting. Immunohistochemical study demonstrated the presence of nuclear protein and hemagglutinin virus antigens in parts of trachea, bronchial epithelium and glands, alveolar epithelium, macrophages and endothelium. Flow cytometry showed that the apoptotic rate of type II pneumocytes (32.15%, 78.15%) was significantly higher than that of the controls (1.93%, 3.77%).</p><p><b>CONCLUSION</b>Necrotizing bronchiolitis, diffuse alveolar damage and pulmonary hemorrhage followed by pulmonary fibrosis in late stage are the major pathologic changes in fatal human influenza A (H1N1) infection.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
/
ODS3 - Meta 3.2 Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
/
Outras Doenças Respiratórias
/
Infecções
/
Doenças Não Transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
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Alvéolos Pulmonares
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Fibrose Pulmonar
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Autopsia
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Virologia
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Biópsia por Agulha
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Proteínas Nucleares
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Bronquiolite Viral
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Mortalidade
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Apoptose
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
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Criança, pré-escolar
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2011
Tipo de documento:
Artigo