New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 591-601, 2008.
Article
em En
| WPRIM
| ID: wpr-359376
Biblioteca responsável:
WPRO
ABSTRACT
The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for the past two decades. Store-operated Ca2+-release-activated Ca2+ (CRAC) channels constitute the sole pathway for Ca2+ entry following antigen-receptor engagement. In a set of breakthrough studies over the past two years, stromal interaction molecule 1 (STIM1, the ER Ca2+ sensor) and Orai1 (a pore-forming subunit of the CRAC channel) have been identified. Here we review these recent studies and the insights they provide into the mechanism of store-operated Ca2+ channels (SOCCs).
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Ligação Proteica
/
Canais de Cálcio
/
Cálcio
/
Sinalização do Cálcio
/
Proteínas de Membrana
/
Metabolismo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2008
Tipo de documento:
Article