Research Advances of IDH2 Gene Mutation in Acute Myeloid Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 632-636, 2016.
Article
em Zh
| WPRIM
| ID: wpr-360034
Biblioteca responsável:
WPRO
ABSTRACT
Acute myeloid leukemia (AML) is a malignant clonal hematologic disease from hematopoietic stem and progenitor cells. The isocitrate dehychogenase 2 (IDH2) gene mutation has been recently found, which may be associated with the course of AML. The incidence of IDH2 gene mutation in the patients with acute myeloid leukemia is high, especially in the AML patients with normal karyotype. Different subtypes of IDH2 mutation, or companing other molecular biology, will make different influence on clinical features and progress of patients with AML. IDH2 mutation is stable, which can be used as the test sign of AML and minimal residual disease (MRD), and for guiding the clinical treatment and predicting the progress. In this article, the research progress of IDH2 mutation in acute myeloid leukemia is reviewed.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Prognóstico
/
Leucemia Mieloide Aguda
/
Neoplasia Residual
/
Genética
/
Isocitrato Desidrogenase
/
Mutação
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2016
Tipo de documento:
Article