MicroRNAs in skeletal muscle / 体力科学
Japanese Journal of Physical Fitness and Sports Medicine
; : 61-70, 2012.
Artigo
em Japonês
| WPRIM (Pacífico Ocidental)
| ID: wpr-363038
Biblioteca responsável:
WPRO
ABSTRACT
Skeletal muscle is the dominant organ in locomotion and energy metabolism so that maintaining skeletal muscle function is a prerequisite for our health and independent living throughout the life. A loss or decrease in skeletal muscle function leads to increased morbidity and mortality through the development of secondary diseases such as metabolic syndrome, type 2 diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The recent discovery of microRNAs (miRNAs) provides a new knowledge controlling skeletal muscle function. miRNAs suppress gene expression through either in inhibition of protein translation or in degradation of the mRNA transcripts through a process similar to RNA interference (RNAi). This review provides the current understanding in skeletal muscle miRNA biology and focuses on their role and regulation under physiological conditions with exercise.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Japonês
Revista:
Japanese Journal of Physical Fitness and Sports Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo