Effect of .BETA.-endorphin on human peripheral lymphocytes / 全日本鍼灸学会雑誌

ABSTRACT

Recently it is well known that human immune system is regulated by various other biological response systems; endocrine and nervous system. We have investigated the effect of electric acupuncture on human immune system for several years. Those studies suggest that electric acupuncture affects human immune system via neuro-immune system. In the present study we investigated the effect of endorphin on human peripheral lymphocytes.<br>At the present concentration of endorphin and naloxone there were no effect on viability of lymphocytes. ³H-thymidine up take of unstimulated lymphocytes were suppressed by a appropriate concentration of endorphin or naloxone. The mitogenic responsiveness of peripheral lymphocytes was suppressed at usual concentration of naloxone and higher concentration of endorphin.<br>In these data suggested that both of intrisic and extrinsic endorphin regulated human lymphocyte responsiveness.