A prospective study of early complications in endoscopic pancreatic sphincterotomy / 中华消化内镜杂志

ABSTRACT

objective To investigate the rate and risk factors of early complications after endoscopic pancreatic sphincterotomy.Methods Data of patients,who underwent endoscopic pancreatic sphincterotomy from May 2006 to April 2007,were recorded before and during the procedure and prospectively studied.The Datients were followed up until discharge.Results A total of 165 patients underwent endoscopic pancreatic sphincterotomy,of which 25(15.2%)developed complications,including acute pancreatitis in 22(13.3%)(15 mild,6 moderate and 1 severe),hemorrhage in 1(0.6%),and acute cholangitis in 2(1.2%).There was no perforation or procedure-related mortality.Multivariate analysis indicated that risk factors of acute pancreatitis were female(OR3.8,95%CI1.4-10.8),recurrent pancreatitis(OR3.1,95%CI1.0-9.9),and parapapilla sphincterotomy(OR5.9,95%CI1.2-28.8).Conclusion Compared with routine ERCP,endoscopic pancreatic sphincterotomy may be associated with higher risk of acute pancreatitis,especiallv in women.patients with recurrent pancreatitis and those undergoing parapapilla sphincterotomy.