Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ / 药学学报

ABSTRACT

The aim of the study is to investigate rat intestinal absorption behavior of three main active components, schisandrol A, schisandrin A and schisandrin B in Schisandra chinensis Baill extracts in intestine of rats. With phenol red as the indicator, in situ single pass intestinal perfusion (SPIP) model was used and the concentrations of three main active components in perfusion solution of different intestinal segments (duodenum, jejunum, ileum, and colon) were determined by HPLC in combination with diode array detection. The results showed that the absorption rate constant (Ka) and effective permeability values (Peff) of three main active components in Schisandra chinensis Baill extracts had significant difference (P 0.05). The absorption of the three active components displayed significant difference (P schisandrin B > schisandrol A in other intestinal segments, and there is significant difference (P < 0.05) between them.