An update of nasal-type extranodal nature killer-T-cell lymphoma / 国际肿瘤学杂志

ABSTRACT

Nasal-type extranodal nature killer-T-cell lymphoma (NKTCL) originates from mature nature killer (NK) cell or NK-like T cell. This lymphoma cells are usually CD3ε, CD56 and Epstein-Barr Virus (EBV) positive and the later plays an important role in the pathogenesis. A number of cell lines and animal models of NKTCL have been established and used in experimental studies. NKTCL always has various chromosome aberrations and the most common is 6q- which are not specific for the disease. Various abnormalities in genes expression and epigenetic also have been found, which might provide potential targets for target therapy in the future.