Clinical Characteristics of Focal Segmental Glomerulosclerosis Recurrence after Adult Renal Transplantation / 대한이식학회지
The Journal of the Korean Society for Transplantation
; : 87-92, 2010.
Article
em Ko
| WPRIM
| ID: wpr-38808
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation is a frequent and still unpredictable complication. Moreover, risk factors for recurrence have not yet been clearly identified. METHODS: We enrolled into our study 2,882 adult kidney recipients who underwent transplantation between April 1979 and April 2009. We retrospectively reviewed clinical manifestations of recurrence of FSGS. RESULTS: Among the 2,784 adult renal recipients, forty four had undergone renal transplantation for primary FSGS. Of the 44, 12 (27.3%) showed recurrent FSGS. Mean duration between transplantation and FSGS recurrence was 22.8+/-37.4 months. There were no significant differences in patient characteristics in the recurrence and non-recurrence groups. The cumulative incidence of FSGS recurrence was 13.8% within 1 year after kidney transplantation and 23.2% within 3 years. The overall graft survival rate in the recurrence group was significantly lower than that of the non-recurrence group (P=0.0018) and non-FSGS group (P=0.0001). Graft failure happened more in the recurrence group (75%) than in the non-recurrence group (37.5%, P=0.042). CONCLUSIONS: We failed to find any significant risk factors for FSGS recurrence after renal transplantation.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Recidiva
/
Glomerulosclerose Segmentar e Focal
/
Incidência
/
Estudos Retrospectivos
/
Fatores de Risco
/
Transplante de Rim
/
Transplantes
/
Sobrevivência de Enxerto
/
Rim
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
Ko
Revista:
The Journal of the Korean Society for Transplantation
Ano de publicação:
2010
Tipo de documento:
Article