Akt/PKB signaling pathway and cerebral ischemia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 149-152, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-394814
Biblioteca responsável:
WPRO
ABSTRACT
After being activated by the growth factor-mediated receptor tyrosine kinase phosphorylation, Akt activates a series of substrate molecules, including Forkhead transcription factors etc, which regulate cell survival and death. With the changes of Akt phosphorylation levels (Ser473) after cerebral ischemia, its upstream and downstream protein phosphorylation levels have also changed. Preconditioning may produce ischemic tolerance by changing the levels of Akt protein phosphoryiation. Dysfunction of Akt/PKB signal transduction pathway may mediated neuronal death after cerebral ischemia.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Journal of Cerebrovascular Diseases
Ano de publicação:
2009
Tipo de documento:
Artigo