Screening the serum proteomic patterns of Paget disease with SELDI-TOF-MS / 中国医师杂志
Journal of Chinese Physician
; (12): 167-169, 2009.
Article
em Zh
| WPRIM
| ID: wpr-395870
Biblioteca responsável:
WPRO
ABSTRACT
Objective To evaluate the diagnostic value of surface enhanced laser desorption/ionization time of flight mass spectrom-etry(SELDI-TOF-MS) for Paget disease. Methods The relative contents of serum proteins of 15 healthy people,15 patients with chronic eczema and 20 patients with Paget were detected by Weak cation exchanger protein chip (WCx2) and SELDI-TOF-MS. Results The con-tents of two proteins (3868Da,8876Da) had significant difference in healthy people and Paget disease patients(P<0.01). 291IDa, 3868Da and 5097Da protein peaks had significant difference in chronic eczema and Paget disease(P<0.05). Conclusion It shows great potentiality for early diagnosis and screening the tumor biomarkers of Paget disease with SELDI-TOF-MS.
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Base de dados:
WPRIM
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
Zh
Revista:
Journal of Chinese Physician
Ano de publicação:
2009
Tipo de documento:
Article