Delta-like ligand 4 and tumour angiogenesis / 国际外科学杂志
International Journal of Surgery
; (12): 116-119, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-396397
Biblioteca responsável:
WPRO
ABSTRACT
Delta-like ligand 4(Dll4), one ligand of Notch receptors, is highly expressed in tumour vessels and is negative regulator in tumour angiogenesis. Blocking Dll4/Notch sinaling could promote tumour angiogenesis, whereas due to poor perrusion of newly forming vessels, tumour growth is inhibited, which is effective even to the tumour patients unresponsive to blocking vascular endothelial growth factor pathway. So, Dll4 is becoming a new promising target in anti-tumour theraties.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Journal of Surgery
Ano de publicação:
2009
Tipo de documento:
Artigo