Compensatory mechanisms of islet β cells In early stage of insulin resistance / 中华内分泌代谢杂志

ABSTRACT

The response of normal islet β cells to insulin resistance is compensatory insulin hypersecretion in order to maintain normoglycemia. The mechanisms involved in the compensation process including the expansion of β cell mass and enhanced β cell performance via various molecular cascades, signaling pathway sand their interactions have been extensively investigated in recent years.