The effect of atorvastatin treatment on C-reative protein and vascular cell adhesion molecule-! in the patients with acute cerebral infarction / 中国基层医药

ABSTRACT

Objective To observe the effect and difference to C-reactive protein(CRP) and vascular cell ad- hesion molecule.1 (VCAM-1), for indicator of inflammainfarction and blood lipid level in acute cerebral( ACI) pa- tients treated with atorvastatin and discuss the impact of early treatment of ACI using statin. Methods 90 ACI in- patients were randomly divided into two groupsone group treated with atorvastatin and the other was not treated with atorvastatin. Their blood levels of TG, TC, LDL-ch, HDL-ch, CRP and VCAM-1 were compared before hospi- talization and on discharge. Results Comparing before admission and on discharge, the blood level of CRP and VCAM-1 were reduced markedly in both group,the blood CRP and VCAM-1 of the former reduced significantly in atorvastatin treatment group and compared with that of the latter on discharge(P < 0.05 ). Conclusion The blood CRP and VCAM-1 level reduced markedly in ACI patients treated with atorvastatin,which suggests that atorvastatin has strong anti-inflammatory effect.