Study on the in vitro antitumor principles of Scutellaria barbata D. Don

ABSTRACT

Isolating and determining molecule structure of compounds with inhibition and killing effect on cancer cell growth of Scutellaria barbata D. Don showed that the first compounds were 8, 13- epoxy-3-en-7-hydroxy-6, 11- O-dibenzoyl-15, 16 clerodanolid. These compounds were a diterpen with high activity of cancer cell growth inhibitor with IC50 value equal 2.15 – 8.3 µM. The compound showed strongest activity on breast cancer (2.15µM (MCF7)) and less activity on carcinoma (8.3 µM (KB). However, the compound showed relative similar activity on prostate cancer and lung cancer cell lines. Thus, the above compound showed cancer cell growth inhibition and killing activity at different level depending on cancer kind