Effects of bioartificial kidney on cardiovascular function and cytokine response in endotoxic shock pigs / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
; (12): 535-540, 2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-402019
Biblioteca responsável:
WPRO
ABSTRACT
Objective To test the role of a bioartificial kidney which consisted of a continuous vein-vein hemofiltration (CVVH) system and renal proximal tubule cells (PTCs)device, also called the renal tubule assist device (RAD),in endotoxin shock.Methods Female crossbred pigs 25 to 30 kg received with 3×1011 bacteria / kg body weight of E.coli intraperitoneally followed by treatment with a sham RAD without cells (n=7) or a RAD with cells (n=7). Data on blood pressure, cardiac output, renal blood flow and systemic marker of inflammation (IL-6) were measured.Results Cardiac outputs and renal blood flows were higher in the RAD group with cells than in the sham RAD group after E.coli infusion (P<0.05). Plasma IL-6 levels were lower in the cell RAD group than in the sham RAD group after bacterial administration (P<0.05). A significant difference on survival time was also observed between the two groups,with(9.07 ± 0.88) h in the cell RAD group vs. (5.10 ± 0.46)h in the sham RAD group, P< 0.01.Conclusion The bioartificial kidney containing PTCs can improve cardiovascular function,reduce cytokine levels,and prolong survival time.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Emergency Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo