Antiviral Activity of the Effective Monomers from Folium Isatidis Against Influenza Virus in Vivo / 中国病毒学·英文版
Virologica Sinica
; (6): 445-451, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-402285
Biblioteca responsável:
WPRO
ABSTRACT
In order to evaluate the anti-influenza virus activity of the effective monomer from Folium Isatidis (FI) in vivo, we established mice model with viral pneumonia and divided them into 3 different dose groups, then observed their lung indexes, pulmonary pathological changes, pulmonary virus hemagglitination titers, living time and death rates. The results showed that the monomer could reduce the pulmonary index from 2.64 to 1.93, 1.63 and 1.40 (P<0.01) and decrease the hemagglitination titer from 1.15 to 0.84, 0.70 and 0.59 (P<0.01). In addition,the living time from 5.1d to 6.5d, 8.4d and 8.9d respectively(P<0.01). The high dose (75 mg/kg/d) has the similar effect with 100 mg/kg/d dose of virazole(P>0.05), and more effective than 200 mg/kg/d dose of antiviral liquor (P<0.05).
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Virologica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo