The Expression of Growth Associated Protein-43 in Inferior Colliculus in Rats after Bilateral Cochlear Ablation / 听力学及言语疾病杂志
Journal of Audiology and Speech Pathology
; (6): 48-51, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-403763
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore the expression of growth associated protein-43(GAP-43)in the inferior colliculus in rats following bilateral cochlear ablation.Methods 35 healthy adult SD rats were randomly divided into 7 groups3,7,14,21,28,90 days following bilateral cochlear ablation and the sham operation group as the control group.The immunohistochemistry was used to observe the expression of GAP-43 after bilateral cochlear ablation in each group.Results GAP-43 was expressed in each group.The GAP-43 expression in bilateral cochlear ablation group were higher than that in the control group.The expression increased at 3 days,followed by a constant increase at 7 to 14 days with the peak on day 14.On day 21 the GAP-43 expression began to decrease.The mean gray level of GAP-43 in all the staining of groups had statistic significance compared to the control group except the group of day 90.However,in all the 7 groups,the mean gray level between the left and right ears had no statistic significance.Conclusion The change of GAP-43 expression in the inferior colliculus following bilateral cochlear ablation reflects synaptic plasticity in inferior colliculus the neurons.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Audiology and Speech Pathology
Ano de publicação:
2010
Tipo de documento:
Artigo