Design and Synthesis of New γ-Secretase Inhibitors / 华中科技大学学报(医学版)
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
; (6): 784-788, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-404853
Biblioteca responsável:
WPRO
ABSTRACT
Objective By virtual screening in MDL,to search for a novel γ-secretase inhibitor.Methods A series of compounds were designed,synthesized,and evaluated based on pharmacophore model of γ-secretase inhibitors by virtual screening in MDL.Results The drug-likeness analytic data synthesized indicated that target compounds had drug-likeness.Each svnthesized compound was checked by IR spectroscopy,~1H and ~(13)C-NMR spectroscopy.Conclusion The designed compounds had better activity by model prediction.And the optimal compound showed a significant estimated activity value of 0.025 nmol/L and can be used as a lead for further drug development.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
Ano de publicação:
2009
Tipo de documento:
Artigo