Pulmonary Diffusing Capacity and BALF Lymphocyte Phenotype in Sarcoidosis / 中国医科大学学报
Journal of China Medical University
; (12): 130-132, 2001.
Article
em Zh
| WPRIM
| ID: wpr-411461
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WPRO
ABSTRACT
Objective: Our aim was to study whether the cellular bronchoalveolar lavage fluid (BALF) profile was associated with the parameters of pulmonary function tests. Methods:Lung function tests and BAL were carried out in 18 untreated, non-smoking patients suffering from sarcoidosis and 18 normal subjects. Results:(1)Lung function tests were normal at rest in patients with sarcoidosis(P>0.05), the single breath carbon monoxide diffusing capacity decreased (P<0.05),and the small airway function decreased too (P<0.05).(2)The percentage of lymphocytes in BALF of sarcoidosis increased comparing with the normal subjects(P<0.01),and the ratio of CD+4 to CD+8 in BALF increased significantly in sarcoidosis(P <0.05), furthermore, the increase of both the percentage of lymphocytes and the ratio of CD+4 to CD+8 in BALF of sarcoidosis were well nagatively correlated with the decrease of the percentage of DLCO (r=-0.67, P<0.01 and r=-0.55, P<0.05, respectively), the decrease of mid-expiratory flow at 50% of vital capacity (FEF50%) was well correlated with the increase of the percentage of lymphocytes in BALF of sarcoidosis (r=-0.54, P<0.05). Conclusion:Pulmonary diffusing capacity(DLCO) was significently correlated with BALF lymphocyte phenotype,so was small airway function,and can act as the marker of activity of sarcoidosis.
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WPRIM
Idioma:
Zh
Revista:
Journal of China Medical University
Ano de publicação:
2001
Tipo de documento:
Article