Effect of BmK-9-(2) on cardiac sodium channels in Guinea-pig ventricular myocytes / 吉林大学学报(医学版)
Journal of Jilin University(Medicine Edition)
; (6): 568-570, 2000.
Article
em Zh
| WPRIM
| ID: wpr-412250
Biblioteca responsável:
WPRO
ABSTRACT
Objective:To investigate the effect of the BmK-9-(2) on the sodium current in guinea-pigventricular myocytes. Methods:The whole cell patch-clamp technique was used. Results:The BmK-9-(2)increased the magnitude of the peak inward sodium current (27 %) ,peak sodium conductace (17 %) and theprolong time course of sodium channel inactivation (8%) and there was no effects on calcium channels.Conclusion:BmK-9-(2) can activate sodium channel and prolong the inactivated course of myocytes.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Jilin University(Medicine Edition)
Ano de publicação:
2000
Tipo de documento:
Article