Nectin-4 expression in pancreatic cancer and its clinical significance / 中华普通外科杂志
Chinese Journal of General Surgery
; (12): 999-1001, 2010.
Article
em Zh
| WPRIM
| ID: wpr-413689
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WPRO
ABSTRACT
Objective To investigate the expressions and the clinical significance of nectin-4 in pancreatic carcinoma and the relationship with clinicopathological features. Methods Immunohistocbemical techniques were used to detect nectin-4 expression in pancreatic carcinoma tissues (n = 40) and normal pancreatic tissues (n = 12 ), and the relationship between the expressions and clinicopathological parameters was analyzed. Results The IOD and area of nectin-4 were 2. 43 ± 0.75 and 9. 73 ± 1.86 in pancreatic carcinoma tissues, which were significantly higher than those in the normal pancreatic tissues( P < 0.01 ).The expression of nectin-4 was not correlated with patients demographics ( P > 0.05 ), and the protein expression was correlated with histopathologic grade ( P < 0.01 ) and lymph metastasis ( P < 0.05 ).Conclusions The high expression of nectin-4 in pancreatic carcinoma tissues suggests that its high expression may be correlated with the malignant degree of the carcinoma. nectin-4 can be considered as a reference index of differentiation, metastasis and prognosis in pancreatic carcinoma.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of General Surgery
Ano de publicação:
2010
Tipo de documento:
Article