Regulatory T cell and tumor immunity / 国际肿瘤学杂志
Journal of International Oncology
; (12): 8-11, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-418032
Biblioteca responsável:
WPRO
ABSTRACT
Regulatory T cells (Treg),a group of negative regulatory cells,have four subsetsCD4+Treg,CD8 + Treg,NKT Treg and DN Treg cells.They play an essential role in the inhibitive immune-regulation and might be the key factors of neoplasms immune escape.These mechanisms include inhibiting the effector cell function by inhibitory cytokines,killing effector cells by granzyme and perforin,competition and inhibiting IL-2,and affecting Treg differentiation and proliferation by regulating the function of CTLA-4,etc.Tumor immunotherapies targeting Treg and related immunosuppressive factors,such as remove Treg or controling the numbers and functions,enhances the immune response against tumors,which might offer a new method of tumor immunotherapy.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Oncology
Ano de publicação:
2012
Tipo de documento:
Artigo