Expression of survivin in congenital choledochal cyst and cholanglocarcinoma / 中华肝胆外科杂志

ABSTRACT

Objective To investigate the expression of survivin and its significance in congenital choledochal cyst and cholangiocarcinoma.Methods Immunohistochemical (S-P) techique was used to detect survivin in 37 patients with congenital choledochal cyst (children,n=20,adult,n=7),and 10 patients with cholangiocarcinoma.Ten patients with normal or benign bile duct lesions were used as control.Results In congenital choledochal cyst,the tissue was strongly positive for 2 patients,positive for 9 patients,weakly positive for 15 patients,and negative for 11 patients.In cholangiocarcinoma,the tissue was strongly positive in 5 patients and positive in 5 patients.In normal bile duct the tissue was weakly positive in 1 patient.The difference among the groups was significant (P＜0.01).The difference in expression of survivin between adults and children with congenital choledochal cyst was significant.Conclusions Survivin may play a pivotal role in malignant change,tumorigenesis,and tumor progression in congenital choledochal cyst.