CD133 molecule on identification of leukemic stem cells from acute leukemia / 国际儿科学杂志

ABSTRACT

Leukemia stem cell might cause relapse and resistance in leukemia.CD133 molecule is a new biomarker of hematopoietic stem,progenitor cell,similar with CD34.In recent years,CD133 has been found to be also expressed in some hematopoietic malignancies,especially in acute leukemia.A remarkable characteristic of CD133 is that the expression of CD133 will be down-regulated as cell differentiation.Therefore,it has become a biomarker to isolate and identify human stem cells and progenitor cells.As a feasible cancer stem cells marker,CD133 plays an important role in sorting cancer stem cells from many solid tumors.Some studies have demonstrated that CD133+ cells are related to signal transduction,immune escape and resistance to medicine and radiation.CD133 is expected to become a new target on leukemia treatment.