Relationship of Vitamin D and preeclampsia / 中国医师进修杂志

ABSTRACT

Objective To study the relationship of Vitamin D and preeclampsia.Methods Four hundred and forty-two pregnant women were enrolled in this study,they were divided into two groups,420women without preeclampsia (control group) and 22 women with preeclampsia (preeclampsia group).Blood serum was collected during the 10th-14th and 24th-28th week of gestation,25-hydroxyvitamin D [25(OH) D]was detected.The level of 25 (OH) D was compared between two groups and Logistic regression analysis was used to investigate the association of 25 (OH) D and preeclampsia.Results The level of 25 (OH) D at 24th-28th week in control group [ (56.3 ± 18.8) nmol/L] was significantly higher than that in preeclampsia group [(46.2 ± 17.4) nmol/L] (P＜0.01).The level of 25 (OH) D had significant relationship with preeclampsia at 24th-28th week (OR =0.67,P =0.01),regression coefficient was -0.3910,Wald was 12.3174.Conclusion The level of 25 (OH) D is associated with preeclampsia at 24th-28th week of gestation.