Heart-type fatty acid binding protein in the early diagnosis of myocardial infarction after off-pump coronary artery bypass / 中华胸心血管外科杂志
Chinese Journal of Thoracic and Cardiovascular Surgery
; (12): 298-301, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-428817
Biblioteca responsável:
WPRO
ABSTRACT
Objective To evaluate the early diagnostic value of Heart-type fatty acid-binding protein(H-FABP) for myocardial infarction in patients post off-pump coronary artery bypass (OPCAB).Methods Between March 2009 and July 2009,59 patients had been undergone OPCAB for the first time.They were divided into 3 groups (normal group,myocardial injury group and myocardial infarction group) by myocardial-bound creatiue kinase (CK-MB) 、cardiac troponio Ⅰ (cTnI) 、electrocardiogram (ECG) and echocardiogram.Serial blood samples were taken during perioperation to quantify blood levels of H-FABP,CK-MB,cTnI.Results The average H-FABP value for the patients in the myocardial infarction group is higher than the others ( P < 0.01 ).H-FABP reached the peak valve at 2 hours and decreased at 4 hours after the patients arrived at ICU.H-FABP got back to the baseline one day postoperation.Receiver operating characteristic curves( ROC curve) demonstrated that H-FABP had greater diagnostic ability of myocardial infarction postoperation with area under the curve at the time of arriving at ICU ( 0.900,95% CI 0.818 -0.981 )and 2 hours later (0.832,95% CI 0.718 -0.946).At the time of arriving at ICU,sensitivity of H-FABP for diagnosis was 90.9% and specificity was 77.1%.At the point of 2 hours later,sensitivity was 72.7% and specificity was 75.0%.Conclusion The H-FABP seems to be an excellent early biomarker of cardiac necrosis after OPCAB.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Estudo de rastreamento
Idioma:
Chinês
Revista:
Chinese Journal of Thoracic and Cardiovascular Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo