Research progress on microRNA polymorphisms and susceptibility of tumor / 肿瘤研究与临床
Cancer Research and Clinic
; (6): 779-782, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-429524
Biblioteca responsável:
WPRO
ABSTRACT
MicroRNA (miRNA) is a class of micro,endogenously-initiated non-coding RNA that negatively regulate gene expression at the post-transcriptional level and involved in tumorigenesis.Polymorphisms in miRNA sequences (miRSNP) alter mature miRNA levels and target mRNA selection.Recent findings have demonstrated that miRSNP mediated epigenetic alteration of miRNA can be one of the mechanism in tumor progression and may play critical role of hallmarks in cancer susceptibility.This review described the most recent advances in the field of hot miRSNP and susceptibility of tumour.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Cancer Research and Clinic
Ano de publicação:
2012
Tipo de documento:
Artigo