Thinking and actuality of induced pluripotent stem cells to treat spinal cord injury / 中国组织工程研究

ABSTRACT

BACKGROUND: Currently, therapies for spinal cord injury include steroid pulse therapy, surgical decompression and stem cel therapy. A lot of work has been focused on stem cel therapy for spinal cord injury which has become a hot spot. OBJECTIVE: To summarize the research status and progress in induced pluripotent stem cells for treatment of spinal cord injury. METHODS: A computer-based online search of PubMed (1980-01/2011-11) was performed for articles in English using the keywords of “spine injury, induced pluripotent stem cells, IPS”RESULTS AND CONCLUSION: A total of 35 articles were included in result analysis, in which, stem cel therapy for treatment of spinal cord injury is agreed or supported. Induced pluripotent stem cells are isolated directly from the body, which solves ethical and moral issues in the transplantation of stem cells, meanwhile avoids al ograft rejection and also provides a large source of cells. Stem cel therapy for spinal cord injury is widely used in animal experiments but few in clinical application. However, stem cel therapy has a good effect in the animal experiments, and shows a higher safety. The existing problems of induced pluripotent stem cells to treat spinal cord injury mainly include immature differentiating method of induced pluripotent stem cells and more complications. Therefore, induced differentiation and security of induced pluripotent stem cells for treatment of spinal cord injury wil become a research key.