Association between plasma homocysteine and high-sensitivity C-response protein in patients with chronic obstructive pulmonary disease / 中国综合临床
Clinical Medicine of China
; (12): 586-590, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-434742
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the functions of blood plasma homocysteine (Hcy) and high sensitivity C-response protein (hs-CRP) in the chronic obstructive pulmonary disease (COPD) in pathogenesis plays,and observe whether there was associations with disease severity and the correlations.Methods Forty-one patients with COPD were collected from August 2010 to February 2011,and 35 healthy persons as control group.Blood plasma Hcy,hs-CRP,forced expiratory volume in one second account predicted (FEV1% predicted),and arterial pressure of oxygen (PaO2,arterial blood gases analysis) were measured in COPD patients and controls.Results Plasma Hcy concentration was (22.07 ± 12.13) μmol/L in COPD patients,but (9.89 ±4.41) μmol/L in controls,there were significant differences between two subjects (t =1.674,P <0.01).COPD patients had a higher serum hs-CRP concentration (8.60±3.85) mg/L than control's (4.24 ±0.57) mg/L (t =1.682,P < 0.01).Along the descent of FEV1% predicted,plasma Hcy and hs-CRP were elevated gradually,both sides show a negative correlation (r =-0.45,-0.49,P < 0.05).And plasma Hcy and hs-CRP present a positive correlation in COPD patients (r =0.68,P < 0.01).Conclusion Plasma Hcy was significantly elevated in COPD patients,positive correlation related to COPD severity and positive correlation related to serum hs-CRP.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Clinical Medicine of China
Ano de publicação:
2013
Tipo de documento:
Artigo