Diagnostic accuracy of serum interleukin-8 in predicting severe acute pancreatitis: a Meta-analysis / 中国医师杂志

ABSTRACT

Objective To investigate the diagnostic accuracy of serum interleukin-8 (IL-8) in predicting severe acute pancreatitis (SAP) by conducting a Meta-analysis.Methods Publications addressing the diagnostic accuracy of serum IL-8 in the diagnosis of SAP were selected from Pubmed,Embase,Cochrane library,CBM,Wanfang,VIP,and CNKI databases.Data analysis was conducted by STATA 9.2software.Results According to the inclusion criteria,five diagnosis tests were retrieved,including 299 SAP patients and 2956 healthy controls.Meta-analysis results showed that the pooled sensitivities of IL-8 were 65.8％and 70.9％ for days 1 and 2,respectively; the pooled specificities were 66.5％ and 91.3％ for days 1 and 2,respectively; the pooled positive predictive value were 54.7 and 86.2 for days 1 and 2,respectively; the pooled negative predictive value were 75.9 and 80.3 for days 1 and 2,respectively; the area under curve (AUC) were 0.73 (95％ CI0.21-0.97) and 0.91 (95％ CI0.85-0.92) for days 1 and 2,respectively; and the diagnostic odds ratio (DOR) were 6.1 (95％ CI2.8-13.2) and 23.4(95 ％ CI8.1-63.7) for days 1 and 2,respectively.Conclusions Serum IL-8 on day 1 and 2 seems to perform high accuracy in predicting SAP,but diagnosis accuracy of serum IL-8 on day 1 was superior than that on day 1.Serum IL-8 might be an important tool for early prediction and diagnosis of SAP.