Study on VNHR 203 strain for safety and efficacy on macaca mulatta monkey

ABSTRACT

Rota virus of the type of G4P6, 8 (VNHR 203) is one of endemic strains in Vietnam causing acute diarrhea in under- five -year -old children. In the year 2000 this strain was isolated from fecal sample of a 9 month boy with acute diarrhoae admitted to St Paul hospital. Viruses were carelully selected and underwent 10 consecutive transferred culturing on Rhesus (MA104) monkey kidney cell medium, then 20 times of assimilating on Macacca mulatta monkey primitive kidney cells.They had got high safety and efficacy in the trial on Macacca mulatta aged 12-24 months