Effect of ginsenosides on the desflurane modulation in the recombinant serotonin type 3A receptor expressed in Xenopus laevis oocytes / 대한마취과학회지
Korean Journal of Anesthesiology
; : 681-686, 2009.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-44234
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Postoperative nausea and vomiting (PONV) is the most frequent and discomforting side effect following general anesthesia. Most volatile anesthetics have a potent effect on serotonin (5-hydroxydtryptamine, 5-HT) type 3 receptor mediating PONV, and their antagonists have been currently used effectively to prevent and/or reduce the incidence and severity of PONV. The authors reported previously that ginsenosides have inhibitory effect on 5-HT3A receptor. In this study we intended to elucidate the inhibitory effect of ginsenosides on the potentiated 5-HT3A receptor by desflurane.METHODS:
After in vitro transcription of the recombinant mouse 5-HT3A receptor in the Xenopus laevis oocyte, we examined the effects of ginsenosides (g-Rb1, g-Rg1, g-Rd, g-Rg2) as well as ginsenoside metabolite, compound K on the modulation of desflurane by measuring currents flowing through 5-HT3A receptor using two-electrode voltage clamp technique.RESULTS:
Although normalized inhibitory responses of ginsenosides were same regardless of desflurane, some ginsenosides such as g-Rd, g-Rg2, and g-Rg1 showed potential inhibition to the enhanced 5-HT induced current of 5-HT3A receptor by desflurane.CONCLUSIONS:
Although ginsenosides have substantial inhibitory effect on 5-HT3A receptor, the effects of ginsenoside on potentiation by desflurane of 5-HT induced current via recombinant 5HT3A receptor may depend on the types of ginsenoside, which suggesting that ginsenoside might have an antagonistic action to nausea and vomiting associated with volatile anesthetics.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oócitos
/
Vômito
/
Xenopus
/
Xenopus laevis
/
Serotonina
/
Incidência
/
Negociação
/
Náusea e Vômito Pós-Operatórios
/
Ginsenosídeos
/
Isoflurano
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2009
Tipo de documento:
Artigo