The analysis of risk factors in gastrointestinal graft versus host disease following allogeneic hematopoietic stem cell transplantation / 中华器官移植杂志
Chinese Journal of Organ Transplantation
; (12): 17-20, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-444410
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the risk factors of gastrointestinal graft versus host disease(GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT).Method 214 patients receiving allo-HSCT from 2003 to 2012 were enrolled in this study,and assessed on the degree of gastrointestinal GVHD.The effects of the primary diseases status,gender,age,conditioning regimen intensity,donor type,the number of cells positive for the CD34 expression,and the use of anti-lymphocyte immunoglobulin (ALG) in the pretreatment scheme on the occurrence of gastrointestinal GVHD was studied.The responses of different degrees of GVHD to immunotherapy were evaluated.Result Univariate and multivariate analyses revealed that the graft type and the conditioning regimen intensity were the risk factors of gastrointestinal GVHD (P<0.05).Conclusion Donor type and conditioningregimen intensity may be the main risk factors of gastrointestinal GVHD.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Idioma:
Chinês
Revista:
Chinese Journal of Organ Transplantation
Ano de publicação:
2014
Tipo de documento:
Artigo