Prognosis after resection of early hepatocellular carcinoma in HBV-related cirrhotic patients / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 258-264, 2014.
Article
em Zh
| WPRIM
| ID: wpr-446691
Biblioteca responsável:
WPRO
ABSTRACT
Objective To identify clinicopathologic factors which predict survival following hepatectomy in HBV-related cirrhotic patients with early hepatocellular carcinoma (HCC).Methods A database was used to identify patients with histologically confirmed early HCC (≤5 cm,no nodal involvement,metastases,or major vascular invasion) who underwent surgical resection (excluding ablation or transplantation).Among 20 700 patients with HCC who were diagnosed at the Eastern Hepatobiliary Surgery Hospital from April 2005 to November 2010,537 (2.6%) patients with early HCC were studied retrospectively.Prognostic factors were evaluated using the Kaplan-Meier curves,Cox proportional hazards models and the receiver operating characteristic (ROC) curves.Results The study included 537 patients.The median tumor size was 2.9 cm,and 33% of patients had tumors ≤2 cm.Most HCC lesions were solitary (63%) and had no evidence of vascular invasion (64%).Following surgery,the overall median and 5-year survival were 45 months and 33% respectively.After adjusting for demographic factors and histological grade,tumor size >2 cm (hazard ratio [HR]:1.56),multifocal tumors (HR:1.34),and vascular invasion (HR:2.03) remained independent predictors of poor survival (all P < 0.05).Based on these findings,a prognostic scoring system was developed that allotted 1 point each for these factors.Patients with early HCC could be stratified into 4 distinct prognostic groups (median and 5-year survival,respectively):0 points (97 months,96%),1 point (85 months,76%),2 points (76 months,54%),3 points (56 months,39%) (P <0.01).Conclusions The present study emphasized the importance of pathologic staging even in patients with small HCC.Anatomical resection of HCC should be the preferred surgical procedure in cirrhotic patients.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
Chinese Journal of Hepatobiliary Surgery
Ano de publicação:
2014
Tipo de documento:
Article