Correlation of serotonin 2A receptor and adenylate cyclase single gene polymorphisms and bipolar disorder / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science
; (12): 200-202, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-447893
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore whether there is association between the polymorphisms of serotonin 2A receptor(5-HT2A) rs6311,rs6305 and adenylate cyclase rs2230739 with episode of bipolar disorder.Methods A case-control association study was done in this study,152 bipolar disorder patients (patients group),and 187 ageand gender-matched controls (control group) were recruited.Ligase detection reaction(LDR) was used to detect the distributive frequency of rs6311,rs6305 and rs2230739 of 152 bipolar disorder patients and 187 normal people.Results The 5-HT2A receptor rs6311 genotypes and alleles frequency distribution between patients group(11,12,22 genotypes21%,61%,18% ; 1,2 alleles51%,49%) and control group(11,12,22 genotypes44%,45%,11% ; 1,2 alleles66%,34%) showed statistically significance (P<0.01).There were no differences of 5-HT2A receptor rs6305 genotypes and alleles between patients group and control group.The frequency of rs2230739 genotypes and alleles distribution between patients group (11,12,22 genotypes 20%,43%,37% ; 1,2 alleles 42%,58%) and control group(11,12,22 genotypes 17%,48%,35% ; 1,2 alleles 41%,59%) showed no significant difference(P=0.661,P=0.846).Conclusion The 5-HT2A receptor rs6311 polymorphism may be responsible for an increase in susceptibility to bipolar disorder,indicating that it maybe an marker to bipolar disorder.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Behavioral Medicine and Brain Science
Ano de publicação:
2014
Tipo de documento:
Artigo