Progress in methodology of establishing physiologically based pharmacokinetic models / 药学学报
Acta Pharmaceutica Sinica
; (12): 16-22, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-448736
Biblioteca responsável:
WPRO
ABSTRACT
Physiologically based pharmacokinetic model (PBPK), a mechanistic mathematic model, which can simulate the absorption, distribution, metabolism and excretion of drugs, is being more widely used in pharmaceutical research and development areas. This article reviews primarily the recent advances in the procedure of establishing a PBPK model, including specifying of the PBPK model structure, specification of the tissue model, writing of equations, set of model parameters, simulation and evaluation. Application significance, major challenges and future developments of PBPK model in pharmaceutical areas are also discussed.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo