Effect of Topiramate on Risperidone-Induced Weight Gain: A Pilot Study / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 468-474, 2005.
Article
em Ko
| WPRIM
| ID: wpr-45308
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: It is known that risperidone induces weight gain moderately which has been previously considered of little clinical concern. And there was no specific effective treatment for atypical antipsychotics-induced weight gain. The study was performed to evaluate the effectiveness of topiramate as an weight-reducing medicine for schizophrenia patients with risperidone-induced weight gain. METHODS: Topiramate, 100-200 mg/day, was administered to 12 schizophrenia patients with risperidone-induced weight gain. Body weight and body mass index (BMI) were measured at baseline, 4-week and 8-week. Brief Psychatric Rating Scale (BPRS) and Positive And Negative Syndrome Scale (PANSS) were used to evaluate psychotic symptoms. RESULTS: Body weight and BMI were decreased significantly at 4-week and 8-week treatment compared to baseline (weight loss: 1.17+/-1.80 kg and 2.50+/-2.24 kg; BMI: -0.41+/-0.65 kg/m2 and -0.88+/-0.82 kg/m2 on 4-week and 8-week). Psychiatric symptoms were improved significantly in BPRS and PANSS. Adverse effects were showed such as fatigue, paresthesia, difficulty in concentration and diarrhea, which were mild and self-limited. CONCLUSION: It is suggested that topiramate have significant effects on patients with risperidone-induced weight gain. Randomized controlled study would be necessary in the near future.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Parestesia
/
Esquizofrenia
/
Peso Corporal
/
Aumento de Peso
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Índice de Massa Corporal
/
Projetos Piloto
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Risperidona
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Diarreia
/
Fadiga
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2005
Tipo de documento:
Article