Exercise Preconditioning Improving the Pathological Cardiac Hypertrophy in Pressure Over-loaded Rats / 中国循环杂志
Chinese Circulation Journal
; (12): 728-732, 2014.
Article
em Zh
| WPRIM
| ID: wpr-453960
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WPRO
ABSTRACT
Objective: To explore the effect of exercise preconditioning (EP) on pathological cardiac hypertrophy and heart failure (HF) in pressure over-loaded experimental rats. Methods:A total of 60 SD rats at the age of 6 weeks were randomly divided into 3 groups, n=20 in each group. Sham-operation group, Transverse aortic constriction (TAC) group and EP + TAC group. The cardiac function and structure were evaluated by echocardiography, patholgical changes and HF biomarkers were examined for EP effect at 4 and 8 weeks after TAC. Results:Compared with Sham-operation group, the cardiac function and structure had obvious changes in the other 2 groups. Compared with TAC group, the ejection fraction in EP+ TAC group increased 15%, the heart weight index and left ventricular weight index decrease 15.7%and 20%respectively at 8 weeks after TAC, all P Conclusion: EP may improve cardiac pathological hypertrophy in pressure over-loaded rats at the early stage, and delay the heart failure process.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Circulation Journal
Ano de publicação:
2014
Tipo de documento:
Article