Preparation of Novel Biocompatible Macromolecular Magnetic Resonance Imaging Contrast Agent / 分析化学
Chinese Journal of Analytical Chemistry
; (12): 1421-1426, 2014.
Article
em Zh
| WPRIM
| ID: wpr-454004
Biblioteca responsável:
WPRO
ABSTRACT
Poly ( aspartic acid-co-leucine) was synthesized, modified via ethylenediamine, conjugated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and finally chelated with gadoliniumⅢ, yielding PL-A2-DOTA-Gd. The T1-relaxivity (15. 3 mmol-1 ·L·s-1 ) of PL-A2-DOTA-Gd was 2. 6 times than that of Gd-DOTA (5. 8 mmol-1·L·s-1) in D2O. The results of magnetic resonance imaging experiments showed significant enhancement in the rat liver after intravenous administration of PL-A2-DOTA-Gd, which persisted longer than Gd-DOTA. The mean percentage enhancements of liver parenchyma were 65. 1%±5. 2%and 21. 3%±4. 9%, for PL-A2-DOTA-Gd and Gd-DOTA, respectively.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Analytical Chemistry
Ano de publicação:
2014
Tipo de documento:
Article