A preparation of captopril sustained release tablet

ABSTRACT

to build formula of captopril sustained release matrix tablets with EC and HPMC, survey the affects of formulation components and optimization of formula by using D- Optimal. Subject captopril, EC, HPMC, lactose, and starch. Method: prepare tablet, assess the quality of captopril sustained release matrix tablets. Conclusions: From the experiment design, captopril sustained release oral tablets with half life of 12h can be prepared, and by optimized method, the proper formula was found. To produce captopril tablets, it's necessary to further study in large scale, to perform test of bio-equivalence and stability of tablet