Coated pellets:the emerging direction of oral modified-release solid dosage forms / 国际药学研究杂志

ABSTRACT

Oral modified-release multiple-unit dosa ge forms such as coated pellets have always been more effective therapeutic alternative to conventional single-unit dosage forms. Coated pellets ranging in size,typically,between 0.5-1.0 mm,are produced primarily for the purpose of oral controlled-release dosage forms having gastro-resistant or sustained-release properties or the capability of site-specific drug delivery. With regards to the final dosage form,the multi-particulates are usually formulated into single-unit dosage forms such as filling them into hard gelatin capsules or compressing them into tablets. As drug-delivery systems become more sophisticated,the role of pellets in the design and development of dosage forms is increasing. The safety and efficacy of the formulation is higher than that of other dosage forms. This review provides an update on this research area and discusses the phenomena and mechanisms of the multi-particulate system concluding multiple-unit pellet system and pellet-containing tablets.