Your browser doesn't support javascript.
loading
Expression and significance of four kinds of serum protein/polypeptide in tuberculosis patients and healthy controls / 实用医学杂志
The Journal of Practical Medicine ; (24): 3769-3771, 2014.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-461661
Biblioteca responsável: WPRO
ABSTRACT
Objective To assess the efficacy of using four kinds of proteins / peptides to distinguish the tuberculosis patients from healthy people. Methods A, B, C and D were used to represent four proteins /peptides with 1 060, 1 944, 2 081 and 3 954 of mass to charge ratio (m / z) in serum, respectively. Levels A, B, C and D in serum of 57 patients with tuberculosis and 30 healthy people were determined by using the surface-enhanced laser desorption-ionization time of flight mass spectrometry (SELDI-TOF-MS). Then the differences of levels of f A, B, C and D were anlyzed between tuberculosis patients and healthy people. The efficacy of distinguishing tuberculosis patient from healthy people were evaluated by using diagnostic test evaluation method. Results (1) The levels of A, B, C and D were 1 ± 11, 1 597 ± 3 102, 460 ± 765 and 1 208 ± 1 003 in tuberculosis patients, while they were 123 ± 201, 47 ± 98, 36 ± 93 and 397 ± 355 in healthy people. (2) The area under the receiver operator characteristic (ROC) curve was 0.644, 0.848, 0.735 and 0.810 respectively. The serum levels of A, B, C and D could be used to distinguish tuberculosis patient from healthy people and the cut-off values of A, B, C and D were ≤166, ≥318, ≥48 and ≥728, respectively. Conclusions B, C and D have better performances to distinguish tuberculosis patients from healthy people , which may be regarded as new promising candidate markers for diagnosis of tuberculosis.

Texto completo: Disponível Contexto em Saúde: Agenda de Saúde Sustentável para as Américas / ODS3 - Saúde e Bem-Estar / Doenças Negligenciadas Problema de saúde: Objetivo 10: Doenças transmissíveis / Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis / Doenças Negligenciadas / Tuberculose Base de dados: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: The Journal of Practical Medicine Ano de publicação: 2014 Tipo de documento: Artigo
Texto completo: Disponível Contexto em Saúde: Agenda de Saúde Sustentável para as Américas / ODS3 - Saúde e Bem-Estar / Doenças Negligenciadas Problema de saúde: Objetivo 10: Doenças transmissíveis / Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis / Doenças Negligenciadas / Tuberculose Base de dados: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: The Journal of Practical Medicine Ano de publicação: 2014 Tipo de documento: Artigo
...