Bone marrow concentrates in regenerative medicine / 中国组织工程研究

ABSTRACT

BACKGROUND:As a mixture of several kinds of stem cels and progenitor cels, autologous bone marrow concentrate has been a research hotspot because of the advantages including easy to obtain, time saving and relatively low cost, which can avoid cel extraction, culture and amplification, and can preferably maintain the bioactivity of cels. OBJECTIVE: To review the current basic research and clinical research on bone marrow concentrate in regenerative medicine. METHODS: A computer-based search of CNKI and PubMed databases was performed for articles relevant to bone marrow concentrate published from January 2000 to February 2015. The key words were bone marrow concentrate, bone marrow mesenchymal stem cels, endothelial progenitor cel in Chinese and English, respectively, which appeared in the title and abstract. Finaly, 62 articles were included in result analysis. RESULTS AND CONCLUSION: Bone marrow concentrate can be harvested by density gradient centrifugation technique, with the advantages of easy to obtain and minimal risk of infection and immunological rejection. Currently, the bone marrow concentrate has been proved to be beneficial to wound healing, tissue regeneration and angiogenesis by numerous studies. Meanwhile, it has been successfuly introduced in clinical application. However, studies about the amount of transplantation are stil in need.